Phenol → 2-Bromo-6-phenoxypyridine

HRID 1183411ノート

反応式

HRID 1183411 の反応式
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[N:3]=1.[C:9]1([OH:15])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.CC(C)([O-])C.[K+]>CS(C)=O>[Br:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([O:15][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:3]=1

参加物

5

反応物 3

HCID 996PhenolHCID 122742,6-DibromopyridineHCID 23665647Potassium tert-butoxide

生成物 1

HCID 8245892-Bromo-6-phenoxypyridine

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

反応条件

温度
160 °C

実験手順

2,6-Dibromo-pyridine (2 g, 8.44 mmol) and phenol (0.794 g, 8.44 mmol) were dissolved in DMSO (20 mL) and potassium tert-butoxide (0.947 g, 8.44 mmol) was added. The reaction was heated to 160° C. overnight then allowed to cool to room temperature. The reaction was submitted to aqueous workup and silica gel chromatography to afford the title compound.

後処理

  1. temperatureto cool to room temperature

出典と根拠

ORDレコード
ord-bfe40919a67f45a39a9a6a44f42e9d2d
出典データセット
uspto-grants-2014_03
特許番号
US08664220B2

反応ノート

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