2,6-ジブロモピリジン

2,6-Dibromopyridine

HCID 12274CAS 626-05-1
部分構造検索類似構造を探す

基本情報

標準SMILES
Brc1cccc(Br)n1
InChIKey
FEYDZHNIIMENOB-UHFFFAOYSA-N
分子式
C5H3Br2N
平均分子量
236.89 g/mol
単同位体質量
234.8632233

名称と識別子

優先名称
2,6-Dibromopyridine
IUPAC
2,6-dibromopyridine
現地名
2,6-ジブロモピリジン
英語名
2,6-Dibromopyridine
分子式
C5H3Br2N
分子量
236.89

名称と別名

2,6-DibromopyridinePYRIDINE, 2,6-DIBROMO-NSC 613EINECS 210-926-9BRN 0108922D9SBA5R353NSC-613DTXSID302116425-20-05-00435 (Beilstein Handbook Reference)RefChem:83149DTXCID60134133210-926-9
名称をさらに表示
2,6-ジブロモピリジン2，6ジブロモピリジン2,6‐ジブロモピリジン2,6-ジブロモピリジン, 98%2,4-dibroMo-6-nitropyridine2,6-dibromo-pyridinLasmiditan Impurity 462,6-Dibromopyridine,98%2,6-Dibromopyridine >2,6-DibroMopyridine, 98% 25GR2,6-Dibromopyridine CAS 626-05-12,6-Dibromopyridine ISO 9001：2015 REACH
FEYDZHNIIMENOB-UHFFFAOYSA-N626-05-12,6-dibromo-pyridineMFCD000062232,6-dibromo pyridineNSC6132,6dibromopyridine2,6-dibrompyridine

データベース識別子

CAS
626-05-1
PubChem CID
12274
DTXSID
DTXSID30211642
UNII
D9SBA5R353
EC Number
210-926-9
Nikkaji
J32.652F

物性

構造計算による物性

XLogP
2.9
極性表面積
12.9 Ų
水素結合供与体数
0
水素結合受容体数
1
回転可能結合数
0
重原子数
8

実験および物理化学的性質

SpringerMaterials Properties15N nuclear magnetic resonance spectrum

物理化学的性質

融点
117 · 117-119 °C (lit.)
沸点
255 °C · 255°C
比重(密度)
2.0383 · 2.0383 (rough estimate)
屈折率
1.58 · 1.5800 (estimate)
闪点
213 °C · 213 °C
貯蔵温度
Keep in dark place,Sealed in dry,Room Temperature

化学的性質

化学的特性White to light yellow crystalline powder

安全と法規制

GHS分類

GHS Classification · 4 件

Danger

H300 (96.7%): Fatal if swallowed [Danger Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P273, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 60 reports by companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory Information · 3 件

Chemical: Pyridine, 2,6-dibromo-

Status: Active Update: 25-05-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/20034

2,6-Dibromopyridine: Does not have an individual approval but may be used under an appropriate group standard

Hazard Classes and CategoriesAcute Tox. 2 (96.7%)
CSL Reaction Information · 6 件

CSL00134

OXYGEN + COPPER(II) CHLORIDE DIHYDRATE + 2,6-DIBROMOPYRIDINE + N-BUTYLLITHIUM + DIETHYL ETHER

O2 reacted with the organocopper (or remaining organolithium) reagent to form some peroxides which exploded

Explosive

Ullmann coupling

ACS Safety Letters

安全データ

wgk
3
rtecs
US7883000
ridadr
2811
hs_code
29333999
risk_code
36/37/38-25-20/21-52-28-52/53-36/38
hazard_code
Xi,T,T+

化学と産業

応用分野 · 3 件

用途有機合成原料。

説明2,6-Dibromopyridine is a halogenated pyridine compound used as a pharmaceutical intermediate in the synthesis of the migraine drug (Lasmiditan).Lasmiditan is an oral prescription drug used to treat acute migraine headaches with or without aura. It is important to note that it is not used for migraine prevention.

使用2,6-Dibromopyridine is used as a tridentate chelating ligand and in the formation of macrocycles containing the terpyridine moiety. It is also used to produce 6-bromo-2-methoxypyridine.

調製方法

純化方法Purify 2,6-dibromopyridine by steam distillation, then recrystallise it twice from EtOH. It does not form an HgCl2 salt. [den Hertog & Wibaut Recl Trav Chim Pays Bas 51 381 1932, Beilstein 20/5 V 435.]

上流・下流製品情報

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