Diethylamine → H-Orn(Z)-OH

HRID 11838

反応式

HRID 11838 の反応式
C([NH:18][C@H:19]([C:34]([OH:36])=[O:35])[CH2:20][CH2:21][CH2:22][NH:23][C:24]([O:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=[O:25])(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O.C(NCC)C>CN(C=O)C>[C:24]([NH:23][CH2:22][CH2:21][CH2:20][C@@H:19]([C:34]([OH:36])=[O:35])[NH2:18])([O:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=[O:25]

参加物

4

反応物 2

HCID 8021DiethylamineHCID 14999635Fmoc-orn(Z)-OH

生成物 1

HCID 7009570H-Orn(Z)-OH収率 199.4%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

The compound obtained in Example 8-5 (122.8 mg) was dissolved in DMF (2.6 ml). After the addition of diethylamine (0.26 ml), the mixture was stirred for 2 hours at room temperature. After the reaction, the solvent was removed by distillation under reduced pressure and the residue was dried under vacuum to obtain the title compound (133.5 mg).

後処理

  1. customAfter the reaction
  2. customthe solvent was removed by distillation under reduced pressure
  3. customthe residue was dried under vacuum

出典と根拠

ORDレコード
ord-5fa1bf7313374de8b97081467abfed33
出典データセット
uspto-grants-2006_08
特許番号
US07098215B2

関連ノート

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