Sodium Bisulfate → HCID 67124545、化合物
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[CH2:13][C:12](=[O:14])[CH2:11][CH2:10][C@H:9]2[C:15]([O-:17])=[O:16])=[CH:4][CH:3]=1.C1([NH2+]C2CCCCC2)CCCCC1.OS([O-])(=O)=O.[Na+]>CCOC(C)=O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C@@H:8]2[CH2:13][C:12](=[O:14])[CH2:11][CH2:10][C@H:9]2[C:15]([OH:17])=[O:16])=[CH:6][CH:7]=1参加物
4
実験手順
A suspension of the product from step C (5 g, 10.46 mmol) in EtOAc (100 mL) was treated with 1M aq NaHSO4 (100 mL) at rt. The biphasic mixture was stirred for 12 h at rt and then separated. The organic layer was washed with water and brine, dried (Na2SO4), filtered and concentrated to afford the title compound. HPLC/MS: 297.0/299.0 (M+1); Rt=2.55 min.
後処理
- customseparated
- washThe organic layer was washed with water and brine
- dry with materialdried (Na2SO4)
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-97cf593752b84c3d832f51155bbe8f58
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08669252B2
反応ノート
読み込み中…