Sodium borohydride → HCID 86680443、化合物

HRID 1184581ノート

反応式

HRID 1184581 の反応式
[O:1]=[C:2]1[CH:6]2[CH2:7][N:8]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:9][CH2:10][N:5]2[CH2:4][CH2:3]1.[BH4-].[Na+]>CO>[OH:1][C@H:2]1[C@@H:6]2[CH2:7][N:8]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:9][CH2:10][N:5]2[CH2:4][CH2:3]1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 83670762HCID 83670762、化合物

生成物 1

HCID 86680443HCID 86680443、化合物収率 43%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of Example 100C (46 g, 0.192 mol) in methanol (460 mL) was added NaBH4 (13 g, 0.345 mol) at approximately 0° C., and the mixture was stirred at ambient temperature for 1 hour. The reaction mixture was quenched with saturated ammonium chloride solution (100 mL), and the he volatiles were removed under reduced pressure. The residue obtained was partitioned between ethyl acetate (500 mL) and water (250 mL). The organic layer was separated, dried over Na2SO4, filtered and concentrated. The material obtained was purified by column chromatography over silica gel using 5-6% methanol in chloroform to get the first eluting product (Example 101A, 5.3 g) and second eluting product (Example 100D, 5.1 g) together with 20 g of a mixture of both diastereomers.

後処理

  1. customThe reaction mixture was quenched with saturated ammonium chloride solution (100 mL)
  2. customthe he volatiles were removed under reduced pressure
  3. customThe residue obtained
  4. customwas partitioned between ethyl acetate (500 mL) and water (250 mL)
  5. customThe organic layer was separated
  6. dry with materialdried over Na2SO4
  7. filtrationfiltered
  8. concentrationconcentrated
  9. customThe material obtained
  10. customwas purified by column chromatography over silica gel using 5-6% methanol in chloroform

出典と根拠

ORDレコード
ord-6908039ddf624c2d8ca1d401aaf0fa3e
出典データセット
uspto-grants-2014_03
特許番号
US08669255B2

反応ノート

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