tert-Butyl (4-methyl-3-nitrophenyl)carbamate → 5-(Boc-amino)-2-methylaniline

HRID 1184837ノート

反応式

HRID 1184837 の反応式
[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH3:14])=[C:10]([N+:15]([O-])=O)[CH:9]=1)([CH3:4])([CH3:3])[CH3:2]>[Pd].C(O)C>[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH3:14])=[C:10]([NH2:15])[CH:9]=1)([CH3:4])([CH3:2])[CH3:3]

参加物

4

反応物 1

HCID 18954623tert-Butyl (4-methyl-3-nitrophenyl)carbamate

生成物 1

HCID 246997865-(Boc-amino)-2-methylaniline収率 96.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

10% palladium on charcoal (6 g) was added to a solution of (4-methyl-3-nitro-phenyl)-carbamic acid tert-butyl ester 26 (60 g, 238 mmol) in ethanol (1200 mL). The mixture was hydrogenated at atmospheric pressure at room temperature for 18 h. The palladium catalyst was removed by filtration over celite and the solvent was removed by evaporation to give (3-Amino-4-methyl-phenyl)-carbamic acid tert-butyl ester 27 (51 g, 96%).

後処理

  1. customThe palladium catalyst was removed by filtration over celite
  2. customthe solvent was removed by evaporation

出典と根拠

ORDレコード
ord-f2c75e4c4dce4a608de3c7a36308b3b2
出典データセット
uspto-grants-2014_03
特許番号
US08669256B2

反応ノート

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