Sodium Hydroxide → 2-Oxo-1,2-dihydrothieno[3,2-b]pyrazine-6-carboxylic acid
反応式
[O:1]=[C:2]1[NH:7][C:6]2[CH:8]=[C:9]([C:11]([O:13]C)=[O:12])[S:10][C:5]=2[N:4]=[CH:3]1.[OH-].[Na+]>CO>[O:1]=[C:2]1[NH:7][C:6]2[CH:8]=[C:9]([C:11]([OH:13])=[O:12])[S:10][C:5]=2[N:4]=[CH:3]1参加物
4
実験手順
To a solution of methyl 2-oxo-1,2-dihydrothieno[3,2-b]pyrazine-6-carboxylate 21 (50 mg, 0.238 mmol) in methanol (3 mL) was added a solution of 2N sodium hydroxide (0.238 mL, 0.476 mmol). The reaction was stirred at rt for 2 h. Quenched with 2N HCl solution and extracted with EtOAc. Organic layer was washed with brine, dried and evaporated to give crude 2-oxo-1,2-dihydrothieno[3,2-b]pyrazine-6-carboxylic acid 84 (27 mg, 57%).
後処理
- customQuenched with 2N HCl solution
- extractionextracted with EtOAc
- washOrganic layer was washed with brine
- customdried
- customevaporated
出典と根拠
- ORDレコード
- ord-5223ab19b26b4888b3501df6d5745985
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08669256B2
反応ノート
読み込み中…