Tert-butyl thieno[2,3-b]pyrazin-6-ylcarbamate → Thieno[2,3-b]pyrazin-6-amine
反応式
[N:1]1[CH:6]=[CH:5][N:4]=[C:3]2[S:7][C:8]([NH:10]C(=O)OC(C)(C)C)=[CH:9][C:2]=12>C(O)(C(F)(F)F)=O.C(Cl)Cl>[N:1]1[CH:6]=[CH:5][N:4]=[C:3]2[S:7][C:8]([NH2:10])=[CH:9][C:2]=12参加物
4
実験手順
A red solution of tert-butyl thieno[2,3-b]pyrazin-6-ylcarbamate (5.09 mmol, 1.28 g) in 66% TFA in CH2Cl2 25 mL was stirred overnight at room temperature The reaction mixture was concentrated in vacuo, dissolved in ethyl acetate, washed with NaHCO3 solution, brine, dried and evaporated to give thieno[2,3-b]pyrazin-6-amine 106 (620 mg, 81%). NMR (400 MHz, DMSO-d6) 5.98 (s, 1H), 7.17 (br s, 2H), 7.93 (d, J=2.7 Hz, 1H), 8.20 (d, J=2.7 Hz, 1H).
後処理
- concentrationwas concentrated in vacuo
- dissolutiondissolved in ethyl acetate
- washwashed with NaHCO3 solution, brine
- customdried
- customevaporated
出典と根拠
- ORDレコード
- ord-a209f3cff04a47af9913001a005bfa9e
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08669256B2
反応ノート
読み込み中…