Thionyl Chloride → 2-Ethoxythieno[2,3-b]pyrazine-6-carbonyl chloride

反応式

[CH2:1]([O:3][C:4]1[N:5]=[C:6]2[CH:12]=[C:11]([C:13]([OH:15])=O)[S:10][C:7]2=[N:8][CH:9]=1)[CH3:2].S(Cl)([Cl:18])=O>>[CH2:1]([O:3][C:4]1[N:5]=[C:6]2[CH:12]=[C:11]([C:13]([Cl:18])=[O:15])[S:10][C:7]2=[N:8][CH:9]=1)[CH3:2]

参加物

反応物 2

HCID 24386Thionyl Chloride

HCID 671255822-Ethoxythieno[2,3-b]pyrazine-6-carboxylic acid

生成物 1

HCID 866801842-Ethoxythieno[2,3-b]pyrazine-6-carbonyl chloride収率 100%

実験手順

A solution of 2-ethoxythieno[2,3-b]pyrazine-6-carboxylic acid (30 mg, 0.134 mmol) in thionyl chloride (1 mL) was stirred at 80° C. for 2 h. Evaporated to dryness and co-evaporated with toluene to give 2-ethoxythieno[2,3-b]pyrazine-6-carbonyl chloride (32 mg, 100%).

後処理

customEvaporated to dryness and co-evaporated with toluene

出典と根拠

ORDレコード: ord-a4ab962234864a819bf86d7102c66b68
出典データセット: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08669256B2

反応ノート

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