Sodium borohydride → 1-(1-(2-Bromoethyl)-3-(2,5-dimethyl-1H-pyrrol-1-yl)-1H-pyrazol-5-yl)ethanol

HRID 1185198ノート

反応式

HRID 1185198 の反応式
[Br:1][CH2:2][CH2:3][N:4]1[C:8]([C:9](=[O:11])[CH3:10])=[CH:7][C:6]([N:12]2[C:16]([CH3:17])=[CH:15][CH:14]=[C:13]2[CH3:18])=[N:5]1.[BH4-].[Na+]>CO>[Br:1][CH2:2][CH2:3][N:4]1[C:8]([CH:9]([OH:11])[CH3:10])=[CH:7][C:6]([N:12]2[C:16]([CH3:17])=[CH:15][CH:14]=[C:13]2[CH3:18])=[N:5]1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 866840481-(1-(2-Bromoethyl)-3-(2,5-dimethyl-1H-pyrrol-1-yl)-1H-pyrazol-5-yl)ethanone

生成物 1

HCID 866840491-(1-(2-Bromoethyl)-3-(2,5-dimethyl-1H-pyrrol-1-yl)-1H-pyrazol-5-yl)ethanol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A 100-mL round-bottomed flask equipped with a magnetic stirrer was charged with 150e (2.1 g, 1.0 eq., 6.8 mmol), NaBH4 (1.29 g, 5.0 eq., 34.0 mmol), and methanol (50 mL). The mixture was stirred at room temperature for 2 h and quenched with water (30 mL). It was then concentrated under reduced pressure and the residue was extracted with dichloromethane (3×50 mL). The combined organic layer was concentrated under reduced pressure to afford crude 150f, which was used in the next step without further purification. MS-ESI: [M+H]+ 311.9

後処理

  1. customA 100-mL round-bottomed flask equipped with a magnetic stirrer
  2. customquenched with water (30 mL)
  3. concentrationIt was then concentrated under reduced pressure
  4. extractionthe residue was extracted with dichloromethane (3×50 mL)
  5. concentrationThe combined organic layer was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-7f3c3d70b82949dea8c1dbfa08da8357
出典データセット
uspto-grants-2014_03
特許番号
US08669251B2

反応ノート

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