Trifluoroacetic acid → 4H,5H,6H-pyrrolo(1,2-b)pyrazol-2-amine

HRID 1185242ノート

反応式

HRID 1185242 の反応式
[N:1]1[N:2]2[CH2:16][CH2:15][CH2:14][C:3]2=[CH:4][C:5]=1[NH:6]C(=O)OC(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[N:1]1[N:2]2[CH2:16][CH2:15][CH2:14][C:3]2=[CH:4][C:5]=1[NH2:6]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 86684089tert-Butyl 5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazol-2-ylcarbamate

生成物 1

HCID 675370624H,5H,6H-pyrrolo(1,2-b)pyrazol-2-amine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 162b (45 mg, 0.20 mmol) in dichloromethane (1.5 mL) was added trifluoroacetic acid (1 mL) at room temperature. The solution was stirred for 5 h. It was then concentrated under reduced pressure to afford 162c which was used in the next step without further purification. MS-ESI: [M+H]+ 124.3

後処理

  1. concentrationIt was then concentrated under reduced pressure

出典と根拠

ORDレコード
ord-5eb4d047a8cf4ddd93e6bedfd93b589a
出典データセット
uspto-grants-2014_03
特許番号
US08669251B2

反応ノート

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