Hydrochloric Acid → 4-Hydroxynaphthalene-2-carboxylic acid

HRID 1185456ノート

反応式

HRID 1185456 の反応式
C([O:3][C:4]([C:6]1[CH:15]=[C:14]([O:16]C(=O)C)[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=1)=[O:5])C.[OH-].[Na+].Cl>C(O)C.O>[OH:16][C:14]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[CH:15]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 364908Ethyl 4-acetoxynaphthalene-2-carboxylate

生成物 1

HCID 130809444-Hydroxynaphthalene-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 19096565Water ethanol溶媒

実験手順

To a solution of 18.5 g of 4-Acetoxy-naphthalene-2-carboxylic acid ethyl ester in 100 ml ethanol/water (9:1), 240 ml of a 1M NaOH was added and stirred for 2 days at RT. Then, the reaction mixture was acidified to pH 2 with diluted hydrochloric acid to precipitate the product. The product was then collected by filtration and dried reduced pressure. Yield: 13.7 g.

後処理

  1. customto precipitate the product
  2. filtrationThe product was then collected by filtration
  3. customdried reduced pressure

出典と根拠

ORDレコード
ord-b3e88b92a4a94147b8b45237a62483e8
出典データセット
uspto-grants-2014_03
特許番号
US08669266B2

反応ノート

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