Trifluoroacetic acid → 4-((R)-2-Amino-3-fluoro-propionyl)-piperazine-1-carboxylic acid ethyl ester
反応式
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][N:9]([C:12](=[O:24])[C@@H:13]([NH:16]C(OC(C)(C)C)=O)[CH2:14][F:15])[CH2:8][CH2:7]1)=[O:5])[CH3:2].C(O)(C(F)(F)F)=O>ClCCl>[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][N:9]([C:12](=[O:24])[C@@H:13]([NH2:16])[CH2:14][F:15])[CH2:8][CH2:7]1)=[O:5])[CH3:2]参加物
4
実験手順
To a solution of 160 mg 4-((R)-2-tert-Butoxycarbonylamino-3-fluoro-propionyl)-piperazine-1-carboxylic acid ethyl ester in 5 ml dichloromethane was added 1.0 ml TFA. After 12 h stirring at RT the solvents were removed and the residue was codistilled twice with toluene. Yield: 216 mg.
後処理
- customwere removed
出典と根拠
- ORDレコード
- ord-283f69e112614254a4fca51bb2e6a17c
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08669266B2
反応ノート
読み込み中…