HCID 68600578、化合物 → HCID 68599400、化合物
反応式
[F:1][C:2]([F:29])([F:28])[CH2:3][CH2:4][O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:27])[CH2:15][NH:16]C(OCC2C=CC=CC=2)=O)[CH2:10][CH2:9]1)=[O:7]>C(O)C.[Pd]>[F:29][C:2]([F:1])([F:28])[CH2:3][CH2:4][O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:27])[CH2:15][NH2:16])[CH2:10][CH2:9]1)=[O:7]参加物
4
実験手順
To a solution of 1.63 g 4-(2-Benzyloxycarbonylamino-acetyl)-piperazine-1-carboxylic acid 3,3,3-trifluoro-propyl ester in 40 ml ethanol were added 200 mg Pd/C (10%) and the suspension stirred under an atmosphere of hydrogen (3 bar) for 12 h. The reaction mixture was filtrated over a plug of Celite®, washed with ethanol and concentrated. Yield: 1.02 g colorless oil.
後処理
- filtrationThe reaction mixture was filtrated over a plug of Celite®
- washwashed with ethanol
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-a31083ba76f64b98a2cbdc0fb7675649
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08669266B2
反応ノート
読み込み中…