HCID 67358291、化合物 → HCID 67357839、化合物

HRID 1185993ノート

反応式

HRID 1185993 の反応式
O[CH:2]([C:6]1([C:19]2[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][CH:20]=2)[N:10]2[CH:11]=[C:12]([C:15]([O:17][CH3:18])=[O:16])[CH:13]=[CH:14][C:9]2=[N:8][CH2:7]1)[C:3]([OH:5])=[O:4]>C(O)=O.[Pd]>[CH3:18][O:17][C:15]([C:12]1[CH:13]=[CH:14][C:9]2[N:10]([C:6]([CH2:2][C:3]([OH:5])=[O:4])([C:19]3[CH:20]=[CH:21][C:22]([CH3:25])=[CH:23][CH:24]=3)[CH2:7][N:8]=2)[CH:11]=1)=[O:16]

参加物

4

反応物 1

HCID 67358291HCID 67358291、化合物

生成物 1

HCID 67357839HCID 67357839、化合物収率 97%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 284Formic Acid溶媒

実験手順

To a solution of 4 (8.5 g, 25 mmol) in formic acid (100 ml) under nitrogen was added 10% palladium/carbon catalyst (600 mg) and the mixture heated at reflux overnight. The mixture was cooled to room temperature, filtered and evaporated to dryness. Water (100 ml) was added and the mixture stirred for 2 h. The white precipitate was filtered, washed with water (2×50 ml) and dried to give the light brown/yellow solid 2-[6-methoxycarbonyl-3-(4-tolyl)imidazo[1,2-a]pyridine-3-yl]acetic acid 5 (7.9 g, 97%).

後処理

  1. temperaturethe mixture heated
  2. temperatureat reflux overnight
  3. filtrationfiltered
  4. customevaporated to dryness
  5. additionWater (100 ml) was added
  6. filtrationThe white precipitate was filtered
  7. washwashed with water (2×50 ml)
  8. customdried

出典と根拠

ORDレコード
ord-45ea17bfe196414d834bc17062081bc5
出典データセット
uspto-grants-2014_03
特許番号
US08673652B2

反応ノート

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