Sodium borohydride → Methyl 4'-(hydroxymethyl)-[1,1'-biphenyl]-2-carboxylate

HRID 1186029ノート

反応式

HRID 1186029 の反応式
[BH4-].[Na+].[CH:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:12]([C:17]([O:19][CH3:20])=[O:18])=[CH:13][CH:14]=[CH:15][CH:16]=2)=[CH:7][CH:6]=1)=[O:4]>CO>[OH:4][CH2:3][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:12]([C:17]([O:19][CH3:20])=[O:18])=[CH:13][CH:14]=[CH:15][CH:16]=2)=[CH:7][CH:6]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 4325150Methyl 2-(4-formylphenyl)benzoate

生成物 1

HCID 15380881Methyl 4'-(hydroxymethyl)-[1,1'-biphenyl]-2-carboxylate収率 99.2%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Sodium borohydride (111 mg) was added to the compound (400 mg) prepared in Example 4 in methanol solution (10 mL) and stirred for 1 hour at room temperature. The reaction mixture was concentrated and extracted with 1 mol/L hydrochloric acid and ethyl acetate. The organic layer was washed with saturated sodium and dried by anhydrous sodium sulfate, and then concentrated to obtain the titled compound (400 mg) having the following physical data.

後処理

  1. concentrationThe reaction mixture was concentrated
  2. extractionextracted with 1 mol/L hydrochloric acid and ethyl acetate
  3. washThe organic layer was washed with saturated sodium
  4. dry with materialdried by anhydrous sodium sulfate
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-ab82958328ea41619d1ccd1c77d93663
出典データセット
uspto-grants-2014_03
特許番号
US08673889B2

反応ノート

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