Sodium Hydroxide → Methyl 2-amino-3-methoxybenzoate

HRID 1186091ノート

反応式

HRID 1186091 の反応式
[CH3:1][O:2][C:3]1[C:8]2[NH:9][C:10](=O)[O:11][C:12](=[O:13])[C:7]=2[CH:6]=[CH:5][CH:4]=1.[OH-].[Na+]>CO.C(OCC)(=O)C>[NH2:9][C:8]1[C:3]([O:2][CH3:1])=[CH:4][CH:5]=[CH:6][C:7]=1[C:12]([O:11][CH3:10])=[O:13]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 105596798-Methoxy-1H-benzo[d][1,3]oxazine-2,4-dione

生成物 1

HCID 602320Methyl 2-amino-3-methoxybenzoate収率 101%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To 8-methoxy-1H-benzo[d][1,3]oxazine-2,4-dione (0.8 g, 4.1 mmol) in anhydrous methanol (25 mL), was added sodium hydroxide (0.24 g, 4.1 mmol) and the mixture was heated to reflux for 2 hours. The solution was cooled, diluted with ethyl acetate, washed with water, saturated sodium bicarbonate, then brine, and dried with sodium sulfate. It was filtered and concentrated to yield methyl 2-amino-3-methoxybenzoate (750 mg, 100%).

後処理

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 2 hours
  3. temperatureThe solution was cooled
  4. washwashed with water, saturated sodium bicarbonate
  5. dry with materialbrine, and dried with sodium sulfate
  6. filtrationIt was filtered
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-8f957ffe94ac44e29d0f38114cd328ba
出典データセット
uspto-grants-2014_03
特許番号
US08673897B2

反応ノート

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