反応式
[N+:1]([C:4]1[CH:11]=[CH:10][CH:9]=[CH:8][C:5]=1[CH2:6][NH2:7])([O-:3])=[O:2].[C:12]([O-])([O-])=O.[K+].[K+].C[CH:19](Br)[C:20]#[N:21]>C(#N)C>[N+:1]([C:4]1[CH:11]=[CH:10][CH:9]=[CH:8][C:5]=1[CH:6]([NH:7][CH2:19][C:20]#[N:21])[CH3:12])([O-:3])=[O:2]参加物
5
反応条件
- 温度
- 65 °C
実験手順
2-Nitrobenzylamine (513 mg, 3.37 mmol) was added to an acetonitrile (40 mL) containing K2CO3 (932 mg, 6.74 mmol) and 2-bromopropanitrile (677 mg, 5.06 mmol) under a nitrogen atmosphere. The reaction mixture was heated to 65° C. for 14 hours. The product (18) was used without purification or concentration in the next step.
後処理
- customThe product (18) was used without purification or concentration in the next step
出典と根拠
- ORDレコード
- ord-7ce1f772d6a549948b571a9eecbe3223
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08673898B2
関連ノート
読み込み中…