2-Thiophenecarboxaldehyde → 2-Thiophenemethanol, a-(trifluoromethyl)-
反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=[O:7].C(=O)([O-])[O-].[K+].[K+].[F:14][C:15]([Si](C)(C)C)([F:17])[F:16]>O1CCCC1.CN(C)C=O>[F:14][C:15]([F:17])([F:16])[CH:6]([C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)[OH:7]参加物
6
実験手順
According to Reference Example 8-2, by use of thiophene-2-carbaldehyde (300 mg, 2.67 mmol) dissolved in tetrahydrofuran (4.5 mL) and N,N-dimethylformamide (1.5 mL), potassium carbonate (74 mg, 0.53 mmol) and (trifluoromethyl)trimethylsilane (0.772 mL, 5.34 mmol), the mixture was stirred and reacted at room temperature for 16 hours. Then, purification by extraction gave 2,2,2-trifluoro-1-(thiophen-2-yl)ethanol (Compound DN) (378 mg, yield: 78%).
後処理
- customreacted at room temperature for 16 hours
- customThen, purification
- extractionby extraction
出典と根拠
- ORDレコード
- ord-f824ac6d7e3b4dc39c2a1b04ff792bfc
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08673908B2
反応ノート
読み込み中…