Potassium Carbonate → HCID 67401954、化合物

HRID 1186371

反応式

HRID 1186371 の反応式
[Cl:1][C:2]1[S:3][C:4]([CH:7]=[O:8])=[CH:5][N:6]=1.C(=O)([O-])[O-].[K+].[K+].[F:15][C:16]([Si](C)(C)C)([F:18])[F:17]>CN(C)C=O>[Cl:1][C:2]1[S:3][C:4]([CH:7]([OH:8])[C:16]([F:18])([F:17])[F:15])=[CH:5][N:6]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 552549(Trifluoromethyl)trimethylsilaneHCID 14797652-Chloro-1,3-thiazole-5-carbaldehyde

生成物 1

HCID 67401954HCID 67401954、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

According to Reference Example 8-2, by use of 2-chlorothiazole-5-carbaldehyde (300 mg, 2.03 mmol) dissolved in N,N-dimethylformamide (4 mL), potassium carbonate (56 mg, 0.41 mmol) and (trifluoromethyl)trimethylsilane (0.360 mL, 2.44 mmol), the mixture was stirred and reacted at room temperature for 1.3 hours. Then, purification by preparative thin-layer chromatography (chloroform/methanol=15/1) was performed to give

後処理

  1. customreacted at room temperature for 1.3 hours
  2. customThen, purification by preparative thin-layer chromatography (chloroform/methanol=15/1)
  3. customto give

出典と根拠

ORDレコード
ord-9fb403dcf9c6448d8721f7ff0532fff1
出典データセット
uspto-grants-2014_03
特許番号
US08673908B2

関連ノート

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