Potassium Carbonate → 2,2,2-Trifluoro-1-(2-morpholinothiazol-5-yl)ethanol

HRID 1186376

反応式

HRID 1186376 の反応式
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[S:8][C:9]([CH:12]=[O:13])=[CH:10][N:11]=2)[CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].[F:20][C:21]([Si](C)(C)C)([F:23])[F:22]>CN(C)C=O>[F:20][C:21]([F:23])([F:22])[CH:12]([C:9]1[S:8][C:7]([N:4]2[CH2:5][CH2:6][O:1][CH2:2][CH2:3]2)=[N:11][CH:10]=1)[OH:13]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 552549(Trifluoromethyl)trimethylsilaneHCID 14797702-(Morpholin-4-yl)-1,3-thiazole-5-carbaldehyde

生成物 1

HCID 674017402,2,2-Trifluoro-1-(2-morpholinothiazol-5-yl)ethanol収率 65.1%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

According to Reference Example 8-2, by use of 2-morpholinothiazole-5-carbaldehyde (177 mg, 0.893 mmol) dissolved in N,N-dimethylformamide (5.3 mL), potassium carbonate (25 mg, 0.18 mmol) and (trifluoromethyl)trimethylsilane (0.198 mL, 1.34 mmol), the mixture was stirred and reacted at room temperature for 2.3 hours. Then, purification by preparative thin-layer chromatography (chloroform/methanol=15/1) was performed to give 2,2,2-trifluoro-1-(2-morpholinothiazol-5-yl)ethanol (Compound DY) (156 mg, yield: 65%).

後処理

  1. customreacted at room temperature for 2.3 hours
  2. customThen, purification by preparative thin-layer chromatography (chloroform/methanol=15/1)

出典と根拠

ORDレコード
ord-c2161b8b710a4619b109609db1ebd983
出典データセット
uspto-grants-2014_03
特許番号
US08673908B2

関連ノート

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