(Trifluoromethyl)trimethylsilane → 2,2,2-Trifluoro-1-(4-methyloxan-4-yl)ethan-1-ol
反応式
[CH3:1][C:2]1([CH:8]=[O:9])[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1.[F-].C([N+](CCCC)(CCCC)CCCC)CCC.[F:28][C:29]([Si](C)(C)C)([F:31])[F:30]>O1CCCC1>[F:28][C:29]([F:31])([F:30])[CH:8]([C:2]1([CH3:1])[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1)[OH:9]参加物
5
実験手順
According to Reference Example 8-12, by use of 4-methyltetrahydro-2H-pyran-4-carbaldehyde (165 mg, 1.29 mmol) dissolved in tetrahydrofuran (5 mL), a 1 mol/L solution of tetrabutylammonium fluoride in tetrahydrofuran (0.258 mL, 0.258 mmol) and (trifluoromethyl)trimethylsilane (0.229 mL, 1.55 mmol), the mixture was stirred and reacted at room temperature for 1.7 hours. Then, purification by extraction gave 2,2,2-trifluoro-1-(4-methyltetrahydro-2H-pyran-4-yl)ethanol (Compound EC) (119 mg, yield: 47%).
後処理
- customreacted at room temperature for 1.7 hours
- customThen, purification
- extractionby extraction
出典と根拠
- ORDレコード
- ord-1c629aebad5f45d1bae09b6c75e861ac
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08673908B2
反応ノート
読み込み中…