[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:7][C:8]([C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1)([CH3:14])[C:9](OCC)=[O:10].O.O.O.O.O.O.O.O.O.O.S([O-])([O-])(=O)=O.[Na+].[Na+]>O1CCCC1>[CH3:14][C:8]([C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1)([CH3:7])[CH2:9][OH:10]Tetrahydrofuran (10 mL) was added to lithium aluminum hydride (75 mg, 2.0 mmol). To this, a solution prepared by dissolving, in tetrahydrofuran (5 mL), ethyl 2-methyl-2-(pyridin-3-yl)propanoate (200 mg, 1.0 mmol) obtained in Step 1 of Reference Example 8-63 was slowly added with cooling in an ice bath, and the mixture was stirred at the same temperature for 1 hour. To this, sodium sulfate decahydrate was added and the mixture was stirred at room temperature for 1 hour. After Celite-filtration, the solvent in the filtrate was evaporated off under reduced pressure. Thus, 2-methyl-2-(pyridin-3-yl)propan-1-ol (Compound EK) (154 mg, yield: 99%) was obtained.
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