(Trifluoromethyl)trimethylsilane → HCID 67402338、化合物
反応式
[CH3:1][N:2]1[CH:7]=[C:6]([CH:8]=[O:9])[CH:5]=[CH:4][C:3]1=[O:10].[F:11][C:12]([Si](C)(C)C)([F:14])[F:13].[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1>[CH3:1][N:2]1[CH:7]=[C:6]([CH:8]([OH:9])[C:12]([F:14])([F:13])[F:11])[CH:5]=[CH:4][C:3]1=[O:10]参加物
5
実験手順
According to Reference Example 8-12, by use of 1-methyl-5-formyl-2-(1H)-pyridone (309 mg, 2.25 mmol), (trifluoromethyl)trimethylsilane (666 μL, 45.1 mmol), tetrabutylammonium fluoride (a 1.0 mol/L solution in tetrahydrofuran, 225 μL, 0.225 mmol) and tetrahydrofuran (10.0 mL), the mixture was stirred and reacted at room temperature fort hour. Then, purification by column chromatography (ethyl acetate) was performed to give 1-methyl-5-(2,2,2-trifluoro-1-hydroxyethyl)-2(1H)-pyridone (Compound ET) (214 mg, yield: 46%).
後処理
- customreacted at room temperature fort hour
- customThen, purification by column chromatography (ethyl acetate)
出典と根拠
- ORDレコード
- ord-cddb6990f52c4aee978a7e5fcef40fd1
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08673908B2
反応ノート
読み込み中…