Isopropylamine → [3-(2-Isopropylamino-pyrimidin-4-yl)-imidazo[1,2-a]pyrazin-8-yl]-(2-methanesulfonyl-ethyl)-amine

HRID 1186470

反応式

HRID 1186470 の反応式
C(OC(=O)[N:7]([C:14]1[C:15]2[N:16]([C:20](Br)=[CH:21][N:22]=2)[CH:17]=[CH:18][N:19]=1)[CH2:8][CH2:9][S:10]([CH3:13])(=[O:12])=[O:11])(C)(C)C.CS[C:27]1[N:32]=[C:31]([Sn](CCCC)(CCCC)CCCC)[CH:30]=[CH:29][N:28]=1.[CH:46]([NH2:49])([CH3:48])[CH3:47]>>[CH:46]([NH:49][C:27]1[N:28]=[C:29]([C:20]2[N:16]3[CH:17]=[CH:18][N:19]=[C:14]([NH:7][CH2:8][CH2:9][S:10]([CH3:13])(=[O:11])=[O:12])[C:15]3=[N:22][CH:21]=2)[CH:30]=[CH:31][N:32]=1)([CH3:48])[CH3:47]

参加物

4

反応物 3

HCID 6363IsopropylamineHCID 27632612-(Methylthio)-4-(tributylstannyl)pyrimidineHCID 68226902(3-Bromo-imidazo[1,2-a]pyrazin-8-yl)-(2-methanesulfonyl-ethyl)-carbamic acid tert-butyl ester

生成物 1

HCID 66548084[3-(2-Isopropylamino-pyrimidin-4-yl)-imidazo[1,2-a]pyrazin-8-yl]-(2-methanesulfonyl-ethyl)-amine

実験手順

[3-(2-Isopropylamino-pyrimidin-4-yl)-imidazo[1,2-a]pyrazin-8-yl]-(2-methanesulfonyl-ethyl)-amine was prepared by a process analogous to that described in Example 12 starting from (3-bromo-imidazo[1,2-a]pyrazin-8-yl)-(2-methanesulfonyl-ethyl)-carbamic acid tert-butyl ester (from Example 5 supra), 2-methylsulfanyl-4-tributylstannanyl-pyrimidine, and isopropylamine. LC-MS: [M+H]+ 376.3.

出典と根拠

ORDレコード
ord-40c6487770b34ddc8fc8aad6e669d823
出典データセット
uspto-grants-2014_03
特許番号
US08673905B2

関連ノート

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