Sodium Azide → 2-(2-Fluoro-4-iodophenylamino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carbonyl azide

HRID 1186763ノート

反応式

HRID 1186763 の反応式
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[N:11]([CH3:28])[C:12](=[O:27])[C:13]([CH3:26])=[CH:14][C:15]=1[C:16](ON1C(=O)CCC1=O)=[O:17].C1COCC1.CC(C)=O.[N-:38]=[N+:39]=[N-:40].[Na+]>O>[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[N:11]([CH3:28])[C:12](=[O:27])[C:13]([CH3:26])=[CH:14][C:15]=1[C:16]([N:38]=[N+:39]=[N-:40])=[O:17]

参加物

5

反応物 3

HCID 33557Sodium AzideHCID 22559816Acetone tetrahydrofuranHCID 866645042,5-Dioxopyrrolidin-1-yl 2-(2-fluoro-4-iodophenylamino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate

生成物 1

HCID 866645052-(2-Fluoro-4-iodophenylamino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carbonyl azide収率 96%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A 100 ml round-bottom flask was charged with 2,5-dioxopyrrolidin-1-yl 2-(2-fluoro-4-iodophenylamino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate (1.2 g, 2.40 mmol) and a mixture of THF/acetone (15 mL/30 mL). To the mixture was added NaN3 (0.52 g, 8 mmol) is previously dissolved in H2O (10 mL). The reaction mixture was stirred art room temperature for 16 hours and the organic solvents were removed under reduced pressure yielding to the desired product as a light brown solid (0.98 g, 96%).

後処理

  1. customthe organic solvents were removed under reduced pressure

出典と根拠

ORDレコード
ord-50d26c6e1f394fc1809b93c2d7e1e113
出典データセット
uspto-grants-2014_03
特許番号
US08673919B2

反応ノート

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