3-Bromo-2-methylbenzoic Acid → (3-Bromo-2-methylphenyl)methanol

HRID 1186924

反応式

HRID 1186924 の反応式
[Br:1][C:2]1[C:3]([CH3:11])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](O)=[O:6]>C1COCC1>[Br:1][C:2]1[C:3]([CH3:11])=[C:4]([CH2:5][OH:6])[CH:8]=[CH:9][CH:10]=1

参加物

3

反応物 1

HCID 27355903-Bromo-2-methylbenzoic Acid

生成物 1

HCID 10035697(3-Bromo-2-methylphenyl)methanol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 3-bromo-2-methyl benzoic acid (35 g, 163 mmol) in THF (200 mL) was added Borane THF Complex (1.0 M, 212 mL, 212 mmol). The mixture was allowed to stir for 24 h. TLC showed one single product spot. The reaction was quenched with water. The solvent THF was removed under reduced pressure. The resulting solid was dissolved in ethyl acetate (500 mL), washed with 1N HCl, sodium carbonate, and brine. The organic layer was dried over sodium sulfate and concentrated to afford (3-bromo-2-methylphenyl)methanol.

後処理

  1. customThe reaction was quenched with water
  2. customThe solvent THF was removed under reduced pressure
  3. dissolutionThe resulting solid was dissolved in ethyl acetate (500 mL)
  4. washwashed with 1N HCl, sodium carbonate, and brine
  5. dry with materialThe organic layer was dried over sodium sulfate
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-e52b7a564f254beabe339bde89660c45
出典データセット
uspto-grants-2014_03
特許番号
US08673920B2

関連ノート

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