3-Bromo-2,5-dimethylbenzoic acid → (3-bromo-2,5-dimethylphenyl)methanol

HRID 1187064ノート

反応式

HRID 1187064 の反応式
[Br:1][C:2]1[C:3]([CH3:12])=[C:4]([CH:8]=[C:9]([CH3:11])[CH:10]=1)[C:5](O)=[O:6]>C1COCC1>[Br:1][C:2]1[C:3]([CH3:12])=[C:4]([CH2:5][OH:6])[CH:8]=[C:9]([CH3:11])[CH:10]=1

参加物

3

反応物 1

HCID 592382453-Bromo-2,5-dimethylbenzoic acid

生成物 1

HCID 10656303(3-bromo-2,5-dimethylphenyl)methanol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 3-bromo-2,5-dimethylbenzoic acid (3.5 g, 15 mmol) in anhydrous THF was added borane THF complex (1.0 M, 25 mL, 25 mmol) at 0° C., then the reaction was warmed to ambient temperature overnight. The reaction was quenched with MeOH and concentrated to afford (3-bromo-2,5-dimethylphenyl)methanol.

後処理

  1. customThe reaction was quenched with MeOH
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-45967cbc690843e1ac8c0cb2df08461b
出典データセット
uspto-grants-2014_03
特許番号
US08673920B2

反応ノート

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