5-(benzyloxy)-2-methylpyridin-4(1H)-one → 5-hydroxy-2-methylpyridin-4(1H)-one

HRID 1187470

反応式

HRID 1187470 の反応式
C([O:8][C:9]1[C:10](=[O:16])[CH:11]=[C:12]([CH3:15])[NH:13][CH:14]=1)C1C=CC=CC=1>CO.O.[Pd]>[OH:8][C:9]1[C:10](=[O:16])[CH:11]=[C:12]([CH3:15])[NH:13][CH:14]=1

参加物

5

反応物 1

HCID 63247195-(benzyloxy)-2-methylpyridin-4(1H)-one

生成物 1

HCID 6426495-hydroxy-2-methylpyridin-4(1H)-one収率 70.5%

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

A solution of 5-benzyloxy-2-methyl-1H-pyridin-4-one (2 g, 9.29 mmol) in methanol (30 ml) and water (8 ml) was placed in a Parr bottle. 10% Pd/C was added and the mixture was hydrogenated at 50 psi for 3 hours. A bed of CELITE™ was placed on a sintered glass, and washed with 0.1N HCl and then water. The content in the Parr bottle was removed from the Parr hydrogenator and flushed with nitrogen. The solution was filtered under suction. The filtrate was evaporated to give a white solid (820 mg, 70% yield).

後処理

  1. washwashed with 0.1N HCl
  2. customThe content in the Parr bottle was removed from the Parr hydrogenator
  3. customflushed with nitrogen
  4. filtrationThe solution was filtered under suction
  5. customThe filtrate was evaporated

出典と根拠

ORDレコード
ord-2b44199cd4514f1d851c7ec6e91eaf55
出典データセット
uspto-grants-2014_03
特許番号
US08673943B2

関連ノート

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