Sodium Bicarbonate → 4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine

HRID 1187623ノート

反応式

HRID 1187623 の反応式
[Cl:1][C:2]1[C:3]2[CH:10]=[C:9]([CH3:11])[N:8](S(C3C=CC=CC=3)(=O)=O)[C:4]=2[N:5]=[CH:6][N:7]=1.CC([O-])(C)C.[K+].C([O-])(O)=O.[Na+]>C1COCC1>[Cl:1][C:2]1[C:3]2[CH:10]=[C:9]([CH3:11])[NH:8][C:4]=2[N:5]=[CH:6][N:7]=1

参加物

5

反応物 3

HCID 516892Sodium BicarbonateHCID 224844987-(Benzenesulfonyl)-4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidineHCID 23665647Potassium tert-butoxide

生成物 1

HCID 3354074-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To the solution of 4-chloro-6-methyl-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine (10 g, 32.5. mmol, 1.0 eq) in THF (400 mL), t-BuOK (18.23 g, 163.0 mmol, 5 eq) was added and stirred at RT for 12 h. Sat. NaHCO3 (50 mL) was added and extracted with EtOAc. The organic layers were separated, dried and concentrated to afford 4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine as a brown solid (2.7 g, 50% in yield).

後処理

  1. extractionextracted with EtOAc
  2. customThe organic layers were separated
  3. customdried
  4. concentrationconcentrated
  5. customto afford

出典と根拠

ORDレコード
ord-2e10dd0b39d949ad9e4b23484476f9bb
出典データセット
uspto-grants-2014_03
特許番号
US08673925B1

反応ノート

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