Lactic Acid → 1,4-Dioxane-2,5-dione, 3,6-dimethyl-, (3R,6S)-rel-

HRID 1188274ノート

反応式

HRID 1188274 の反応式
[C:1]([OH:6])(=[O:5])[CH:2]([CH3:4])[OH:3].C(O)(=O)[CH2:8][CH2:9][C:10](O)=[O:11]>>[CH3:4][C@H:2]1[O:3][C:10](=[O:11])[C@H:9]([CH3:8])[O:6][C:1]1=[O:5]

参加物

3

反応物 2

HCID 612Lactic AcidHCID 1110Succinic Acid

生成物 1

HCID 69503741,4-Dioxane-2,5-dione, 3,6-dimethyl-, (3R,6S)-rel-

実験手順

Succinic anhydride is often a significant component of the intermediate-boiling impurities. Succinic anhydride can be separated from meso-lactide by washing the meso-lactide stream with a weakly basic aqueous phase. A suitable pH of the washing solution is in the range of from about 7.2 to about 11. This is believed to hydrolyze the succinic anhydride to form succinic acid. Some of the lactide may also be hydrolyzed to form mainly linear oligomers and possibly some lactic acid. The succinic acid is much more soluble in the basic aqueous phase than in the lactide phase, and will partition to the aqueous phase. The aqueous and organic phases are then separated to form a washed meso-lactide stream having a reduced level of succinic anhydride and perhaps other intermediate-boiling impurities. The washed meso-lactide stream can be recycled as described before.

後処理

  1. customwill partition to the aqueous phase
  2. customThe aqueous and organic phases are then separated

出典と根拠

ORDレコード
ord-f1e3b6ac61c74cd7855dd0e0402bbbb5
出典データセット
uspto-grants-2014_03
特許番号
US08674056B2

反応ノート

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