Piperazine → 2-Methyl-1-(4-methylsulfanylphenyl)-2-piperazin-1-yl-propan-1-one

HRID 1188296

反応式

HRID 1188296 の反応式
CO[C:3]1([C:8]2[CH:13]=[CH:12][C:11]([S:14][CH3:15])=[CH:10][CH:9]=2)[C:5]([CH3:7])([CH3:6])[O:4]1.[NH:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>ClCCl>[CH3:6][C:5]([N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1)([CH3:7])[C:3]([C:8]1[CH:13]=[CH:12][C:11]([S:14][CH3:15])=[CH:10][CH:9]=1)=[O:4]

参加物

4

反応物 2

HCID 4837PiperazineHCID 201925252-Methoxy-3,3-dimethyl-2-(4-methylsulfanylphenyl)oxirane

生成物 1

HCID 233257252-Methyl-1-(4-methylsulfanylphenyl)-2-piperazin-1-yl-propan-1-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
130 °C

実験手順

Further, in a 500 mL four-neck flask provided with a stirrer, a condenser, and a thermocouple, the compound (c) and 31 g of piperazine were added, followed by stirring at 130° C. for 6 hours. After cooling, 80 mL of dichloromethane was added, and an organic layer was washed three times with 70 mL of water. The organic layer was dried with anhydrous sodium sulfate and concentrated to produce 60.7 g of 2-methyl-1-(4-methylsulfanylphenyl)-2-piperazin-1-yl-propan-1-one (12).

後処理

  1. customFurther, in a 500 mL four-neck flask provided with a stirrer, a condenser
  2. temperatureAfter cooling
  3. washan organic layer was washed three times with 70 mL of water
  4. dry with materialThe organic layer was dried with anhydrous sodium sulfate
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-924c4bc3a53c456787de4b2d41573fe2
出典データセット
uspto-grants-2014_03
特許番号
US08674089B2

関連ノート

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