関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Piperazine | HCID 4837 | — |
| 反応物 | 2-Methoxy-3,3-dimethyl-2-(4-methylsulfanylphenyl)oxirane | HCID 20192525 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-Methyl-1-(4-methylsulfanylphenyl)-2-piperazin-1-yl-propan-1-one | HCID 23325725 | — |
反応手順
Further, in a 500 mL four-neck flask provided with a stirrer, a condenser, and a thermocouple, the compound (c) and 31 g of piperazine were added, followed by stirring at 130° C. for 6 hours. After cooling, 80 mL of dichloromethane was added, and an organic layer was washed three times with 70 mL of water. The organic layer was dried with anhydrous sodium sulfate and concentrated to produce 60.7 g of 2-methyl-1-(4-methylsulfanylphenyl)-2-piperazin-1-yl-propan-1-one (12).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08674089B2 |
|---|
| 出典データセット | uspto-grants-2014_03 |
|---|
| ORD ID | ord-924c4bc3a53c456787de4b2d41573fe2 |
|---|
| 出典メモ | uspto-grants-2014_03 |
|---|
