反应详情

温度

130 °C

Further, in a 500 mL four-neck flask provided with a stirrer, a condenser, and a thermocouple, the compound (c) and 31 g of piperazine were added, followed by stirring at 130° C. for 6 hours. After cooling, 80 mL of dichloromethane was added, and an organic layer was washed three times with 70 mL of water. The organic layer was dried with anhydrous sodium sulfate and concentrated to produce 60.7 g of 2-methyl-1-(4-methylsulfanylphenyl)-2-piperazin-1-yl-propan-1-one (12).

1. customFurther, in a 500 mL four-neck flask provided with a stirrer, a condenser
2. temperatureAfter cooling
3. washan organic layer was washed three times with 70 mL of water
4. dry with materialThe organic layer was dried with anhydrous sodium sulfate
5. concentrationconcentrated