L-Phenylalanine → (2S,5S)-tert-Butyl-5-(2'-iodo-4'-methoxybenzyl)-2-tert-butyl-3-methyl-4-oxoimidazolidine-1-carboxylate

HRID 1188755ノート

反応式

HRID 1188755 の反応式
N[C@H](C(O)=O)CC1C=CC=CC=1.[C:13]([CH:17]1[N:21]([CH3:22])[C:20](=[O:23])[CH2:19][N:18]1[C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])([CH3:16])([CH3:15])[CH3:14].C(NC(C)C)(C)C.[Li]CCCC.C(OC(N1CC(=O)N(C)[C@@H]1C(C)(C)C)=O)(C)(C)C.Br[CH2:62][C:63]1[CH:68]=[CH:67][C:66]([O:69][CH3:70])=[CH:65][C:64]=1[I:71].[NH4+].[Cl-]>C1COCC1>[C:27]([O:26][C:24]([N:18]1[C@@H:19]([CH2:62][C:63]2[CH:68]=[CH:67][C:66]([O:69][CH3:70])=[CH:65][C:64]=2[I:71])[C:20](=[O:23])[N:21]([CH3:22])[C@@H:17]1[C:13]([CH3:16])([CH3:14])[CH3:15])=[O:25])([CH3:30])([CH3:29])[CH3:28]

参加物

9

反応物 7

HCID 6140L-PhenylalanineHCID 7912DiisopropylamineHCID 25517Ammonium ChlorideHCID 546472(R)-1-Boc-2-tert-butyl-3-methyl-4-imidazolidinoneHCID 688132(S)-tert-Butyl 2-(tert-butyl)-3-methyl-4-oxoimidazolidine-1-carboxylateHCID 112096011-(Bromomethyl)-2-iodo-4-methoxybenzeneHCID 178418339Butyllithium

生成物 1

HCID 11306634(2S,5S)-tert-Butyl-5-(2'-iodo-4'-methoxybenzyl)-2-tert-butyl-3-methyl-4-oxoimidazolidine-1-carboxylate収率 23%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
-78 °C

実験手順

This product was obtained using the general procedure reported in the literature [(D. Seebach, E. Dziadulewicz, L. Behrendt, S. Cantoreggi, R. Fitzi, “Synthesis of Nonproteinogenic (R)- or (S)-Amino Acids Analogues of Phenylalanine, Isotopically Labelled and Cyclic Amino Acids from tert-Butyl 2-(tert-Butyl)-3-methyl-4-oxo-1-imidazolidinecarboxylate (Boc-BMI).” Liebigs Ann. Chem., pp 1215-1232 (1989)]. Diisopropylamine (0.9 mL, 6.4 mmol) dissolved in dry THF (5 mL) was cooled to −78° C. under argon and a solution of BuLi (2.5 M in hexane, 2.5 mL) was added drop wise. After 20 min of stirring at −78° C., a solution of (S)-tert-butyl-2-tert-butyl-3-methyl-4-oxoimidazolidine-1-carboxylate (3.0 g, 11.9 mmol) was added drop wise and the reaction mixture was stirred for 30 min at −40° C. A solution of 2-iodo-4-methoxybenzyl bromide (20) (2.08 g, 6.4 mmol) in dry THF (2 mL) was then added drop wise to the reaction mixture. The new reaction mixture was stirred for 2 hours at the same temperature and then poured into a saturated solution of NH4Cl. The product was extracted with EtOAc and the organic layer was washed with NaHCO3 solution followed by brine. The organic phase was dried over anhydrous Na2SO4, filtered and evaporated to produce a yellow oil. Flash chromatographic purification of the oily product provided pure (2S,5S)-tert-Butyl-5-(2′-iodo-4′-methoxybenzyl)-2-tert-butyl-3-methyl-4-oxoimida-zolidine-1-carboxylate (27) as a white solid (743.7 mg, 23%).

後処理

  1. customThis product was obtained
  2. stirringthe reaction mixture was stirred for 30 min at −40° C
  3. stirringThe new reaction mixture was stirred for 2 hours at the same temperature
  4. extractionThe product was extracted with EtOAc
  5. washthe organic layer was washed with NaHCO3 solution
  6. dry with materialThe organic phase was dried over anhydrous Na2SO4
  7. filtrationfiltered
  8. customevaporated
  9. customto produce a yellow oil
  10. customFlash chromatographic purification of the oily product

出典と根拠

ORDレコード
ord-ac79cc7e37224872b356d2629f8fb6e0
出典データセット
uspto-grants-2014_03
特許番号
US08674101B2

反応ノート

読み込み中…