Acetone → (E)-4-(2,4-difluorophenyl)but-3-en-2-one
反応式
[F:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:3]=1[CH:4]=O.[CH3:11][C:12]([CH3:14])=[O:13].[OH-].[Na+]>O>[F:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:3]=1/[CH:4]=[CH:11]/[C:12](=[O:13])[CH3:14]参加物
5
実験手順
To a mixture of 2,4-difluorobenzaldehyde (5.0 ml, 45.7 mmol) and acetone (10.75 ml, 146 mmol) in Water (10 ml), was added 0.25M sodium hydroxide (18.30 ml, 4.57 mmol). The reaction mixture was heated to for 2 h. The mixture was poured into ice water. It was extracted with ethyl acetate (200 ml). The organic layer was dried, filtered, and evaporated to give (E)-4-(2,4-difluorophenyl)but-3-en-2-one as yellow oil. It was used for the next reaction without purification. 1H NMR (CDCl3/400 MHz): δ (ppm) 7.60 (d, 1H), 7.60-7.53 (m, 1H), 6.96-6.86 (m, 2H), 6.73 (d, 1H), 2.39 (s, 3H).
後処理
- temperatureThe reaction mixture was heated to for 2 h
- extractionIt was extracted with ethyl acetate (200 ml)
- customThe organic layer was dried
- filtrationfiltered
- customevaporated
出典と根拠
- ORDレコード
- ord-5185cd3713a448b7a379a6b0f8ac835b
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08674115B2
反応ノート
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