Triethylsilane → ethyl 2-(2-(2-hydroxyethyl)-3,5-dimethyl-4-(4-(pyrrolidin-1-ylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetate

HRID 1189567ノート

反応式

HRID 1189567 の反応式
FC(F)(F)S(O[Si](C)(C)C)(=O)=O.[CH3:13][C:14]1[N:18]([CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:17]2[CH2:25][CH2:26][O:27][CH2:28][C:16]=2[CH:15]=1.[N:29]1([S:34]([C:37]2[CH:44]=[CH:43][C:40]([CH:41]=O)=[CH:39][CH:38]=2)(=[O:36])=[O:35])[CH2:33][CH2:32][CH2:31][CH2:30]1.C([SiH](CC)CC)C>C(Cl)Cl>[OH:27][CH2:26][CH2:25][C:17]1[N:18]([CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:14]([CH3:13])=[C:15]([CH2:41][C:40]2[CH:43]=[CH:44][C:37]([S:34]([N:29]3[CH2:33][CH2:32][CH2:31][CH2:30]3)(=[O:36])=[O:35])=[CH:38][CH:39]=2)[C:16]=1[CH3:28]

参加物

6

反応物 4

HCID 12052TriethylsilaneHCID 65367Trimethylsilyl triflateHCID 58310957ethyl 2-(2-methyl-6,7-dihydropyrano[4,3-b]pyrrol-1(4H)-yl)acetateHCID 585641144-(Pyrrolidine-1-sulfonyl)benzaldehyde

生成物 1

HCID 58310958ethyl 2-(2-(2-hydroxyethyl)-3,5-dimethyl-4-(4-(pyrrolidin-1-ylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetate収率 33.9%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

反応条件

温度
0 °C

実験手順

To a flame-dried vial was charged with DCM (2 ml) and trimethylsilyl trifluoromethanesulfonate (0.081 ml, 0.448 mmol) was added at 0° C., followed by a solution of ethyl 2-(2-methyl-6,7-dihydropyrano[4,3-b]pyrrol-1(4H)-yl)acetate (50 mg, 0.224 mmol) and 4-(pyrrolidin-1-ylsulfonyl)benzaldehyde (53.6 mg, 0.224 mmol) in CH2Cl2 (5 ml) (cannulated), the mix was stirred at 0° C. for 15 min, neat triethylsilane (0.143 ml, 0.896 mmol) was added slowly, stirred for 30 min at 0° C., then slowly warmed to r.t. TLC confirmed that reaction was done. Therefore, it was quenched with sat. NaHCO3, extracted with DCM. Combined DCM was dried with Na2SO4, filtered and concentrated under vacuum. The residue was chromatographed on silica using a Biotage automated system (5-30-50% ethyl acetate/hexanes) to give ethyl 2-(2-(2-hydroxyethyl)-3,5-dimethyl-4-(4-(pyrrolidin-1-ylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetate (34 mg, 0.076 mmol, 33.8% yield).

後処理

  1. additionwas added at 0° C.
  2. stirringstirred for 30 min at 0° C.
  3. temperatureslowly warmed to r.t
  4. customTLC confirmed that reaction
  5. customTherefore, it was quenched with sat. NaHCO3
  6. extractionextracted with DCM
  7. dry with materialCombined DCM was dried with Na2SO4
  8. filtrationfiltered
  9. concentrationconcentrated under vacuum
  10. customThe residue was chromatographed on silica using a Biotage

出典と根拠

ORDレコード
ord-81b88e78c53349f5af8f990a2f92b4db
出典データセット
uspto-grants-2014_03
特許番号
US08674115B2

反応ノート

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