Pivaloyl chloride → N-(3-Nitro-2,4-dichloro-benzyl)-2,2-dimethyl-propionamide

HRID 1189613ノート

反応式

HRID 1189613 の反応式
[CH3:1][C:2]([CH3:7])([CH3:6])[C:3](Cl)=[O:4].[N+:8]([C:11]1[C:12]([Cl:20])=[C:13]([CH:16]=[CH:17][C:18]=1[Cl:19])[CH2:14][NH2:15])([O-:10])=[O:9]>C1COCC1>[N+:8]([C:11]1[C:12]([Cl:20])=[C:13]([CH:16]=[CH:17][C:18]=1[Cl:19])[CH2:14][NH:15][C:3](=[O:4])[C:2]([CH3:7])([CH3:6])[CH3:1])([O-:10])=[O:9]

参加物

4

反応物 2

HCID 62493Pivaloyl chlorideHCID 56839971(2,4-Dichloro-3-nitrophenyl)methanamine

生成物 1

HCID 67958116N-(3-Nitro-2,4-dichloro-benzyl)-2,2-dimethyl-propionamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

2,2-Dimethyl-propionic acid chloride (0.124 mL, 1.01 mmol) is added to a mixture of 3-nitro-2,4-dichloro-benzylamine (0.28 g, 1.01 mmol) and TEA (0.35 mL, 2.52 mmol) in THF (10 mL) and it is stirred overnight. The reaction mixture is concentrated, diluted with EtOAc, washed successively with 5% aq NaHCO3 solution and brine, dried with Na2SO4 filtered and concentrated.

後処理

  1. concentrationThe reaction mixture is concentrated
  2. additiondiluted with EtOAc
  3. washwashed successively with 5% aq NaHCO3 solution and brine
  4. dry with materialdried with Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-6649cb7489694018beeaf1b92f667bad
出典データセット
uspto-grants-2014_03
特許番号
US08674113B2

反応ノート

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