Nitric Acid → 2-Chloro-4-fluoro-3-methyl-5-nitrobenzoic acid

HRID 1189676ノート

反応式

HRID 1189676 の反応式
[N+:1]([O-:4])(O)=[O:2].[Cl:5][C:6]1[C:14]([CH3:15])=[C:13]([F:16])[CH:12]=[CH:11][C:7]=1[C:8]([OH:10])=[O:9].OS(O)(=O)=O>>[Cl:5][C:6]1[C:14]([CH3:15])=[C:13]([F:16])[C:12]([N+:1]([O-:4])=[O:2])=[CH:11][C:7]=1[C:8]([OH:10])=[O:9]

参加物

4

反応物 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 108453152-Chloro-4-fluoro-3-methylbenzoic acid

生成物 1

HCID 105138312-Chloro-4-fluoro-3-methyl-5-nitrobenzoic acid

実験手順

Aq HNO3 (65%, 0.39 mL) is added at 0° C. to a mixture of 2-chloro-3-methyl-4-fluoro-benzoic acid (880 mg, 4.7 mmol) and 8 mL conc H2SO4 and it is stirred for 2 h without further cooling. The mixture is poured into ice water and the precipitate is collected by filtration and dried.

後処理

  1. filtrationthe precipitate is collected by filtration
  2. customdried

出典と根拠

ORDレコード
ord-da14ae3dc166415aa27d3a794a378cf8
出典データセット
uspto-grants-2014_03
特許番号
US08674113B2

反応ノート

読み込み中…