Methanol → Methyl 2-chloro-4-(methylamino)-5-nitrobenzoate

HRID 1189685ノート

反応式

HRID 1189685 の反応式
S(Cl)(Cl)=O.[Cl:5][C:6]1[CH:14]=[C:13]([NH:15][CH3:16])[C:12]([N+:17]([O-:19])=[O:18])=[CH:11][C:7]=1[C:8]([OH:10])=[O:9].[CH3:20]O>>[CH3:20][O:9][C:8](=[O:10])[C:7]1[CH:11]=[C:12]([N+:17]([O-:19])=[O:18])[C:13]([NH:15][CH3:16])=[CH:14][C:6]=1[Cl:5]

参加物

4

反応物 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 679575072-Chloro-4-(methylamino)-5-nitrobenzoic acid

生成物 1

HCID 67957559Methyl 2-chloro-4-(methylamino)-5-nitrobenzoate

実験手順

Thionylchloride (3.87 g, 32 mmol) is added dropwise at rt to a mixture of 2-chloro-4-methylamino-5-nitro-benzoic acid (5.00 g, 22 mmol) and 45 mL MeOH and it is stirred at reflux overnight. The mixture is cooled to rt and the precipitate is collected by filtration and dried. Yield: 5.01 g. MS m/z: 245 [M+H]+.

後処理

  1. temperatureat reflux overnight
  2. filtrationthe precipitate is collected by filtration
  3. customdried

出典と根拠

ORDレコード
ord-17cd38c7ba6c4b629211428c8b58e90a
出典データセット
uspto-grants-2014_03
特許番号
US08674113B2

反応ノート

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