Dimethylamine, hydrochloride → HCID 178493497、化合物

HRID 1189910ノート

反応式

HRID 1189910 の反応式
Cl.[CH3:2][NH:3][CH3:4].[CH:5]([C:7]1[N:8]=[C:9]([NH:12][C:13]([C:15]2[C:16]3[N:17]=[CH:18][CH:19]=[N:20][C:21]=3[C:22]([C:25]3[C:30]([F:31])=[C:29]([O:32][CH3:33])[CH:28]=[C:27]([O:34][CH3:35])[C:26]=3[F:36])=[CH:23][CH:24]=2)=[O:14])[NH:10][CH:11]=1)=O>C(Cl)Cl.CO>[CH3:2][N:3]([CH2:5][C:7]1[N:8]=[C:9]([NH:12][C:13]([C:15]2[C:16]3[N:17]=[CH:18][CH:19]=[N:20][C:21]=3[C:22]([C:25]3[C:30]([F:31])=[C:29]([O:32][CH3:33])[CH:28]=[C:27]([O:34][CH3:35])[C:26]=3[F:36])=[CH:23][CH:24]=2)=[O:14])[NH:10][CH:11]=1)[CH3:4]

参加物

4

反応物 2

HCID 10473Dimethylamine, hydrochlorideHCID 178493498HCID 178493498、化合物

生成物 1

HCID 178493497HCID 178493497、化合物

試薬・触媒・溶媒 1

HCID 21226129Dichloromethane methanol溶媒

実験手順

The title compound was prepared in analogy to the procedure described in Example 180 but using dimethylamine hydrochloride (1.5 equiv) instead of N,N,N′-trimethylethylenediamine and 8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid (4-formyl-1H-imidazol-2-yl)-amide (Example 7). Title compound: ES-MS: 469 [M+H]+; tR=3.14 min (System 1); TLC: Rf=0.22 (DCM/MeOH/NH3aq, 91.5:7.5:1).

後処理

  1. customThe title compound was prepared in analogy to the procedure

出典と根拠

ORDレコード
ord-e62e7f0a59ad4b40a5c157b011333072
出典データセット
uspto-grants-2014_03
特許番号
US08674099B2

反応ノート

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