HCID 66747402、化合物 → HCID 66747249、化合物
反応式
[OH:1][B:2]1[CH2:7][CH:6]=[CH:5][CH:4]([CH2:8][C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[O:3]1>CCOC(C)=O.[Pd]>[OH:1][B:2]1[CH2:7][CH2:6][CH2:5][CH:4]([CH2:8][C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[O:3]1参加物
4
実験手順
To a solution of tert-butyl 2-(2-hydroxy-3,6-dihydro-2H-1,2-oxaborinin-6-yl)acetate XLVII (670 mg, 3.16 mmol) in EtOAc (45 mL) was added 10% Pd/C (135 mg). The vessel was evacuated by applying vacuum and flushed with hydrogen gas. The reaction was stirred under hydrogen for 2 h. The mixture was filtered through a Celite pad and which was washed with additional EtOAc (15 mL). Concentration of the filtrate gave pure tert-butyl 2-(2-hydroxy-1,2-oxaborinan-6-yl)acetate XLVIII (641 mg, 3.00 mmol, 94.8% yield).
後処理
- customThe vessel was evacuated
- customflushed with hydrogen gas
- filtrationThe mixture was filtered through a Celite pad and which
- washwas washed with additional EtOAc (15 mL)
出典と根拠
- ORDレコード
- ord-970e287999624395a900c304e0595681
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08680136B2
反応ノート
読み込み中…