N,N-Dimethylethylenediamine → 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-N-(2-dimethylaminoethyl)-4-nitro-thiophene-2-carboxamide

HRID 1192080

反応式

HRID 1192080 の反応式
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([OH:16])=O)=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[CH3:21][N:22]([CH3:26])[CH2:23][CH2:24][NH2:25]>>[Cl:20][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([NH:25][CH2:24][CH2:23][N:22]([CH3:26])[CH3:21])=[O:16])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

参加物

3

反応物 2

HCID 66053N,N-DimethylethylenediamineHCID 602073175-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxylic acid

生成物 1

HCID 469324265-[(3,5-dichloro-4-pyridyl)sulfanyl]-N-(2-dimethylaminoethyl)-4-nitro-thiophene-2-carboxamide

実験手順

Prepared according to the procedure described for example 44 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (35 mg, 0.1 mmol) and N′,N′-dimethylethane-1,2-diamine (7.3 mg, 0.12 mmol). The title compound was obtained as a solid (5.8 mg, 14.8% yield). MS m/z: 421.90, 423.90 [M+H]+.

後処理

  1. customPrepared

出典と根拠

ORDレコード
ord-4c0fa69905dc4b519e28515ba4e131af
出典データセット
uspto-grants-2014_03
特許番号
US08680139B2

関連ノート

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