Dichloromethane → HCID 12547487、化合物
反応式
FC(F)(F)C(O)=O.ClCCl.C(OC([NH:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][CH2:27][C:28]#[N:29])=[CH:21][CH:20]=1)=O)(C)(C)C>>[NH2:18][C:19]1[CH:20]=[CH:21][C:22]([CH2:25][CH2:26][CH2:27][C:28]#[N:29])=[CH:23][CH:24]=1参加物
4
実験手順
A 0.25 M solution of trifluoroacetic acid in dichloromethane (5 mL, 1.25 mmol) was added to 4-[4-(t-Butoxycarbonylamino)phenyl]butanenitrile (98) (0.22 g, 0.85 mmol). After 30 min, reaction was quenched with 1 N NaOH solution. The mixture was partitioned with ethyl acetate (30 mL) and water (20 mL). The organic layer was dried over MgSO4, concentrated to give 4-(4-Aminophenyl)butanenitrile (97) (0.16 g, 99%) which was used without further purification.
後処理
- customreaction
- customwas quenched with 1 N NaOH solution
- customThe mixture was partitioned with ethyl acetate (30 mL) and water (20 mL)
- dry with materialThe organic layer was dried over MgSO4
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-90839db4885f4328bf12b150234d3526
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08680291B2
反応ノート
読み込み中…