Sodium Hydroxide → 4-(2-Fluoro-4-nitrophenyl)butanoic acid

HRID 1192866ノート

反応式

HRID 1192866 の反応式
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[CH2:11][CH2:12][CH2:13][C:14]([O:16]C)=[O:15].[OH-].[Na+]>CO.O>[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[CH2:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 57672633Methyl 4-(2-fluoro-4-nitrophenyl)butanoate

生成物 1

HCID 576726244-(2-Fluoro-4-nitrophenyl)butanoic acid収率 98%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

反応条件

温度
21 °C

実験手順

To a solution of Methyl 4-(2-fluoro-4-nitrophenyl)butanoate (84) (43 mg, 0.18 mmol) in methanol (1 mL) and water (3 mL) was added sodium hydroxide (0.18 g, 4.50 mmol). The reaction mixture was stirred at 21° C. overnight. The reaction mixture was quenched with 1 N HCl solution and extracted with ethyl acetate (2×30 mL). The organic layer was dried over MgSO4, concentrated to give 4-(2-Fluoro-4-nitrophenyl)butanoic acid (82) (40 mg, 98%) and the residue was used without further purification.

後処理

  1. customThe reaction mixture was quenched with 1 N HCl solution
  2. extractionextracted with ethyl acetate (2×30 mL)
  3. dry with materialThe organic layer was dried over MgSO4
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-c71ece2c8d0646d6ac844b492fcb7d6f
出典データセット
uspto-grants-2014_03
特許番号
US08680291B2

反応ノート

読み込み中…