Trifluoroacetic acid → HCID 67116508、化合物
反応式
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:8]=[CH:7][N:6]=[C:5]([N:9]2[C@@H:16]3[C@@H:11]([CH2:12][CH2:13][N:14](C(OC(C)(C)C)=O)[CH2:15]3)[CH2:10]2)[N:4]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:25][C:2]([F:1])([F:24])[C:3]1[CH:8]=[CH:7][N:6]=[C:5]([N:9]2[C@@H:16]3[C@@H:11]([CH2:12][CH2:13][NH:14][CH2:15]3)[CH2:10]2)[N:4]=1参加物
4
実験手順
To (1R,6S)-tert-butyl 8-(4-(trifluoromethyl)pyrimidin-2-yl)-3,8-diazabicyclo[4.2.0]octane-3-carboxylate (185 mg, 0.5 mmol) in DCM (3 mL) was added TFA (3 mL). After 3 h, the reaction was concentrated, neutralized with 5% Na2CO3 (aq) and extracted with DCM (3×). The combined organics were dried (Na2SO4) and concentrated to give the title compound that was used without further purification. MS (ESI) mass calcd. For C11H13F3N4, 258.2; m/z found 259.1 [M+H]+