Methanol → 3-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid
反応式
[CH3:1][C:2]1[C:3]([N:10]2[N:14]=[CH:13][CH:12]=[N:11]2)=[C:4]([CH:7]=[CH:8][CH:9]=1)[C:5]#N.[OH-:15].[Na+].C[OH:18]>O>[CH3:1][C:2]1[C:3]([N:10]2[N:14]=[CH:13][CH:12]=[N:11]2)=[C:4]([CH:7]=[CH:8][CH:9]=1)[C:5]([OH:18])=[O:15]参加物
5
反応条件
- 温度
- 90 °C
実験手順
To a solution of 3-methyl-2-(2H-1,2,3-triazol-2-yl)benzonitrile (1.4 g, 7.82 mmol) in MeOH (15 mL) was added a 4N aqueous solution of NaOH (10 mL). The resulting mixture was heated to 90° C. After 15 h the reaction mixture was cooled to ambient temperature then diluted with water (50 mL). The aqueous layer was acidified to pH2 and extracted with EtOAc (50 mL) three times. The organic layers were combined, dried over Na2SO4, filtered and concentrated.
後処理
- temperatureAfter 15 h the reaction mixture was cooled to ambient temperature
- extractionextracted with EtOAc (50 mL) three times
- dry with materialdried over Na2SO4
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-8449263808a54a5f9fea5e7a6e7676fa
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08680275B2
反応ノート
読み込み中…