Trifluoroacetic acid → (R)-Methyl 3-amino-2,3-dihydro-1H-indene-5-carboxylate

HRID 1193251ノート

反応式

HRID 1193251 の反応式
C(O)(C(F)(F)F)=O.C(OC([NH:15][C@H:16]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([C:25]([O:27][CH3:28])=[O:26])[CH:23]=2)[CH2:18][CH2:17]1)=O)(C)(C)C>ClCCl>[NH2:15][C@H:16]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([C:25]([O:27][CH3:28])=[O:26])[CH:23]=2)[CH2:18][CH2:17]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 59505324Methyl (R)-3-((tert-butoxycarbonyl)amino)-2,3-dihydro-1H-indene-5-carboxylate

生成物 1

HCID 55278060(R)-Methyl 3-amino-2,3-dihydro-1H-indene-5-carboxylate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

TFA (10 ml) was added dropwise at 0° C. to a solution of (R)-methyl 3-(tert-butoxycarbonyl-amino)-2,3-dihydro-1H-indene-5-carboxylate (2.3 g, 7.9 mmol, 1 eq) in dichloromethane (50 ml), and stirring was carried out for 1 h at RT. Then the solvent was reduced under reduced pressure. The crude product was used in the following stage without being purified and analyzed further.

後処理

  1. customwithout being purified

出典と根拠

ORDレコード
ord-2d1d2022ac6a44558d9643b512d68ce2
出典データセット
uspto-grants-2014_03
特許番号
US08680159B2

反応ノート

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