Trifluoroacetic acid → Benzyl methyl(piperidin-4-yl)carbamate

HRID 1193373ノート

反応式

HRID 1193373 の反応式
[CH2:1]([O:8][C:9]([N:11]([CH3:25])[CH:12]1[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:25][N:11]([CH:12]1[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]1)[C:9](=[O:10])[O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 57753905HCID 57753905、化合物

生成物 1

HCID 18677746Benzyl methyl(piperidin-4-yl)carbamate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

tert-Butyl 4-((benzyloxycarbonyl)(methyl)amino)piperidine-1-carboxylate (0.3 g, 0.682 mmol, 1.0 eq.) was dissolved in DCM (10 ml); TFA (2.5 ml) was added at 0° C. and stirring was carried out for 2 hours at RT. The reaction mixture was concentrated under reduced pressure, taken up several times in toluene and dried. The crude product was used in the next stage without being purified further.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customdried
  3. customwithout being purified further

出典と根拠

ORDレコード
ord-8e1110e4de924ff7a4f9d7cb88be3303
出典データセット
uspto-grants-2014_03
特許番号
US08680159B2

反応ノート

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