Trifluoroacetic acid → N-methyl-1-(1-methyl-1H-imidazol-2-yl)piperidin-4-amine

HRID 1193394ノート

反応式

HRID 1193394 の反応式
FC(F)(F)C(O)=O.[CH3:8][N:9]([CH:17]1[CH2:22][CH2:21][N:20]([C:23]2[N:24]([CH3:28])[CH:25]=[CH:26][N:27]=2)[CH2:19][CH2:18]1)C(=O)OC(C)(C)C>ClCCl>[CH3:8][NH:9][CH:17]1[CH2:22][CH2:21][N:20]([C:23]2[N:24]([CH3:28])[CH:25]=[CH:26][N:27]=2)[CH2:19][CH2:18]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 66798554tert-Butyl methyl(1-(1-methyl-1H-imidazol-2-yl)piperidin-4-yl)carbamate

生成物 1

HCID 62131647N-methyl-1-(1-methyl-1H-imidazol-2-yl)piperidin-4-amine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Trifluoroacetic acid (1 ml) was added at 0° C. to a solution of tert-butyl methyl(1-(1-methyl-1H-imidazol-2-yl)piperidin-4-yl)carbamate (241 mg, 0.82 mmol, 1 eq) in dichloromethane (5 ml), and the reaction mixture was stirred for 1 h at room temperature. Concentration under reduced pressure was then carried out. The crude product so obtained was used in the next stage without being purified further.

後処理

  1. concentrationConcentration under reduced pressure

出典と根拠

ORDレコード
ord-291a5f2cf6774ef689cf7e3b58fdc86f
出典データセット
uspto-grants-2014_03
特許番号
US08680159B2

反応ノート

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